Protein Details: Inward rectifier potassium channel 13

Function

Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised; the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ13 has a very low single channel conductance; low sensitivity to block by external barium and cesium; and no dependence of its inward rectification properties on the internal blocking particle magnesium

Sequence

PDB Structures

Ligand Binding